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Fentanyl Patches

238.00480.00

Fentanyl patches are a transdermal opioid pain medication used to manage severe, long-term pain that requires continuous relief. They deliver fentanyl, a synthetic opioid that is 50 to 100 times more potent than morphine, directly through the skin into the bloodstream over a period of 72 hours.

These patches are only prescribed for patients who are opioid-tolerant and have chronic pain conditions that cannot be managed with other pain medications.

Uses of Fentanyl Patches

  1. Chronic Pain Management:

    • Used for patients with cancer pain, severe back pain, or terminal illnesses.

    • Often prescribed in palliative care or hospice settings.

  2. Opioid-Tolerant Patients:

    • Only given to individuals who have been on high-dose opioids for a long time.

    • Not recommended for first-time opioid users due to overdose risks.


How Fentanyl Patches Work

  • The patch slowly releases fentanyl through the skin into the bloodstream.

  • It provides continuous pain relief for up to 72 hours, reducing the need for frequent dosing.

  • Works by binding to opioid receptors in the brain and spinal cord, blocking pain signals and inducing a sedative, euphoric effect.


Common Brand Names & Variants

  • Duragesic (Brand-name fentanyl patch)

  • Generic fentanyl transdermal system

  • Available in doses of 12 mcg/hr, 25 mcg/hr, 50 mcg/hr, 75 mcg/hr, and 100 mcg/hr


Dosage & Administration

  • The patch is applied to clean, dry, non-irritated skin (chest, back, side, or upper arm).

  • It should be replaced every 72 hours (some patients may require 48-hour replacement).

  • Do not cut or tamper with the patch, as it can release too much fentanyl at once.

  • Avoid heat exposure (hot showers, heating pads), which can increase fentanyl absorption and lead to overdose.


Side Effects

Common Side Effects:

  • Drowsiness & dizziness

  • Nausea, vomiting, & constipation

  • Sweating & itching at the patch site

  • Dry mouth

Serious Side Effects (Seek Medical Attention):

  • Respiratory depression (slow or shallow breathing)

  • Severe sedation or unconsciousness

  • Confusion, hallucinations, or mood changes

  • Overdose symptoms (pinpoint pupils, cold skin, slowed breathing)


Warnings & Precautions

  • High Risk of Overdose & Death

    • Fentanyl is extremely potent and should never be used by opioid-naïve patients.

    • Accidental exposure (especially in children) can be fatal.

  • Addiction & Dependence

    • Long-term use can lead to physical dependence & withdrawal symptoms.

  • Heat Sensitivity

    • Avoid hot showers, saunas, or heating pads while wearing the patch.

  • Drug Interactions

    • Avoid mixing with alcohol, benzodiazepines, or other CNS depressants, which can increase overdose risk.


Overdose Risk & Treatment

  • Overdose Symptoms:

    • Severe respiratory depression (slow or stopped breathing)

    • Extreme drowsiness or unconsciousness

    • Cold, clammy skin & pinpoint pupils

Transdermal Film

15 film of 12 mcg/hr, 15 film of 25 mcg/hr, 15 film of 37.5 mcg/hr, 15 film of 50 mcg/hr, 15 film of 62.5 mcg/hr, 15 film of 75 mcg/hr, 15 film of 87.5 mcg/hr, 15 film of 100 mcg/hr

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