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JWH-250 is a synthetic cannabinoid belonging to the naphthoylindole class of compounds. It is a potent agonist at CB1 and CB2 receptors, mimicking the effects of tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis. It was originally developed by John W. Huffman, a chemist who synthesized a wide variety of cannabinoids for research purposes to understand the effects of cannabinoid receptors. Like other synthetic cannabinoids, JWH-250 is often found in “Spice” or “K2” products, which are marketed as legal alternatives to cannabis. However it is much more potent than THC, making it more likely to cause adverse effects and health risks.