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How Dilaudid Works

• Hydromorphone, the active ingredient in Dilaudid, binds to opioid receptors in the central nervous system (CNS), reducing the perception of pain.

• It also causes sedation, euphoria, and respiratory depression, making it effective but highly addictive.

Common Brand Names & Variants

• Dilaudid (Immediate-Release Tablets)

• Exalgo (Extended-Release Tablets)

• Hydromorphone Generic Tablets.

• Also available in oral liquid, injectable, and suppository forms

Dosage & Administration

• Dilaudid tablets come in strengths of 2 mg, 4 mg, and 8 mg.

• Usually taken every 4 to 6 hours as needed for pain.

• Extended-release (Exalgo) is taken once daily for chronic pain.

• Should be taken with or without food, with a full glass of water

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Side Effects

Common Side Effects:

• Drowsiness & dizziness

• Nausea & vomiting

• Constipation (common with opioids)

• Dry mouth

• Sweating

Serious Side Effects (Seek Medical Attention):

• Respiratory depression (slow or shallow breathing)

• Severe sedation or loss of consciousness

• Low blood pressure (lightheadedness, fainting)

• Hallucinations, confusion, or mood changes

• Addiction, dependence, or withdrawal symptoms

Dilaudid is significantly stronger than morphine—approximately 4 to 5 times more potent—and is typically prescribed for severe pain that does not respond to weaker opioids.

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